Clathrin, caveolin, Rabs (Rab4, Rab5A, Rab1A, Rab2A) as well as their effectors (Rab25, Vav1, Rab coupling protein,cdc42, VSP39), can contribute to the processes of cancer cell survival and metastasis, and cancer stem cell emergence [36–38] (Table 1). The gene discussed is VAV1; the disease is cancer.