Clathrin, caveolin, Rabs (Rab4, Rab5A, Rab1A, Rab2A) as well as their effectors (Rab25, Vav1, Rab coupling protein,cdc42, VSP39), can contribute to the processes of cancer cell survival and metastasis, and cancer stem cell emergence [36–38] (Table 1). This evidence concerns the gene RAB1A and cancer.