The vc linker is specifically designed to be cleaved by the lysosomal enzyme, cathepsin B. CD30 is a transmembrane protein of the TNF receptor 3 superfamily restrictively expressed on activated B and T cells at low levels in normal tissues and over-expressed on their malignant counterparts in Hodgkin lymphoma (HL) and anaplastic large cell lymphoma [46]. This evidence concerns the gene TNFRSF8 and Hodgkins lymphoma.