This suggests that lycopene can prevent increases in serum TC, TG, and LDL-C, enhance the activity of brain LDLR, promote cholesterol transport, and indirectly adjust the brain TC, TG, and LDL-C levels; further, it can reduce the production of ox-LDL, IL-1, and TNF-α and alleviate the injury due to inflammatory and oxidative stress in hyperlipidemia. The gene discussed is LDLR; the disease is hyperlipidemia.