In particular, ETBR is overexpresssed in bladder carcinoma [24], melanoma [25], small-cell lung cancer [26], vulvar cancer [5], clear-cell renal cell carcinoma [6], oesophageal squamous cell carcinoma [7], and astrocytoma (including GBM) [12]. This evidence concerns the gene EDNRB and small cell lung carcinoma.