EDNRB and central nervous system cancer: Since ethnicity may play a major role in the pathogenesis of gliomas [13, 14], we investigated whether ETBR overexpression could be detected in patients with GBM and in other cancers outside of China, whether ETBR expression correlates with patient survival (and thus its potential use as a prognostic marker and/or therapeutic target), and whether clinically available endothelin receptor blockers/antagonists have toxic effects on cancer cells in vitro.