This study reports the results of a meta-analysis that was performed: i) to compare HtrA1 expression as protein and mRNA, in cancer tissue (C) versus non-cancer tissue, i.e. healthy control (HC) tissue and normal-looking (NL) tissue; and ii) to assess overall survival in relation to low or medium-high HtrA1 tissue expression in different cancers. This evidence concerns the gene HTRA1 and cancer.