HTRA1 and hepatocellular carcinoma: Finally, the different HtrA1 expression, found in papers assessing the same cancer type, could correlate to histological grading, metastasis, and degree of cell differentiation, but were not related to patients’ age or gender, as demonstrated in hepatocellular carcinoma [12], esophageal carcinoma [35, 36] and endometrial cancer [10, 40, 41].