The current study demonstrated the following findings: (1) patients with CAD exhibited lower BDNF levels and higher vWF levels than those of control patients; (2) low BDNF levels were associated with high vWF levels, as an indicator of endothelial dysfunction; (3) the presence of low BDNF and high vWF levels was associated with adverse cardiovascular events at 12-month follow-up in these patients. This evidence concerns the gene BDNF and endothelial dysfunction.