MOG and Peripheral demyelination: However, while expression of MOG driven by the CMV or the fascin1 promoter in combination with pCMV-TGFß resulted in a clear reduction of CNS-infiltrating macrophages and T cells (see Fig 3; S2 Fig) as well as Th1/Th17 T effector cell populations (see Fig 4), axonal demyelination was significantly reduced only in the case of CMV promoter-driven MOG expression.