CD274 and colorectal carcinoma: Interestingly, we observed a lower CRC risk when PD-L1 rs2890657 interacted with the allele of the NLRC5 rs12445252, which is predicted to decrease NLRC5 expression (-0.26 and a p-value of 1.6e-7), while the interaction between the different genotype categories of PD-L1 rs822338 and NLRC5 rs289726 was more complex, implicating an increased CRC risk for genotype combinations including rs289726 alleles predicted to either increase or decrease NLRC5 expression.