In this study, we included only four of the many immune-related genes for several reasons: first because of the interesting opposite effect that NLRC5 and PD-L1 exert on the regulation of T-cell mediated immunity, second because both of them are downstream targets of IFNγ and third because of the emerging role of these genes on CRC as well as on other cancer types. This evidence concerns the gene NLRC5 and cancer.