Logistic regression analysis adjusted for age and sex reported an association between rectal cancer risk and 2 NLRC5 SNPs, rs1684575 (OR: 1.60, 95% CI: 1.13–2.27, recessive model) and rs3751710 (OR: 0.70, 95% CI: 0.51–0.96, dominant model) (S2 Table). Here, NLRC5 is linked to rectal cancer.