NLRC5 and colorectal carcinoma: Furthermore, the two 3’UTR SNPs in NLRC5, rs43216 and rs27194 (r2 = 0.43), exhibited a decreased risk of CRC, which may be due to the interaction between the alleles that are predicted to bind a higher number of miRNAs than the other allele, leading to a stricter NLRC5 post-transcriptional repression.