Type I IFN receptor (IFNAR)-deficient (IFNAR-/-) mice infected with WNV all die within 4 days post-infection (p.i.)with doses of WNV that produce little or no death in wildtype (WT) mice [10], while mice lacking the type 3 IFN receptor chain IL-28Rα, exhibit increased CNS infection concomitant with loss of blood brain barrier integrity [12]. Here, IFNAR1 is linked to infection.