IRS1 and infection: The increase in phospho-signaling of several proteins including HSP27 (S82), IRS-1 (S612), p38/MAPK (T180/Y182), p53 (S15), and p90RSK (S380) during RVFV infection mirrored prior analysis with ZH501, thus indicating a strong correlation between differing RVFV strains to alter similar host signaling pathways [20].