Therefore, a small subset of these potential Smad-regulated genes that demonstrated a 2-fold or greater difference by RNASeq were included for ChIP analysis; these targets are COL6A3 and IL1R2 (hepatic fibrosis/stellate cell activation), SEMA6A, SEMA7A, SLIT3, SRGAP3, and UNC5A (axonal guidance), and VAV3 (Tec kinase signaling; Table 3). The gene discussed is IL1R2; the disease is fibrosis.