Previous work from our group has shown that mRNA transcripts of cardiac KLF15 are lowered in rodent and human samples of heart failure, and that the mouse with global loss of KLF15 is more susceptible to heart failure following pressure overload, suggesting a role for KLF15 regulation of fatty acid oxidation in the context of heart failure [8, 16, 31, 32]. Here, KLF15 is linked to heart failure.