To obtain a clear picture of the etiopathogenesis of RA, we investigated the relationship of serological disease marker (RF, ERS, CRP and anti-CCP antibody) levels with arthritis severity (SJC28, TJC28, DAS28-ESR and pVAS), and hematological maker (lymphocytes, WBC and Hb) levels (Figs 6–9). This evidence concerns the gene CRP and Arthritis.