AGT and Hypertension: 2014). We propose that in our previous study, the more robust response to AngII+ salt causes a breakdown of the blood–brain barrier, allowing AngII to access noncircumventricular organ sympathoexcitatory centers in the brain. This is consistent with the report that RDNX attenuates hypertension induced by chronic intracerebroventricular infusion of AngII in rats consuming a high salt diet (Osborn and Camara 1997).