LMNA and neoplasm: In this study, we identified Smurf2, a HECT type E3 ubiquitin ligase and recently discovered tumor suppressor (Blank et al., 2012; Emanuelli et al., 2017; Zou, Levy‐Cohen & Blank, 2015), as the essential regulator of stability and protein turnover of lamin A and its disease‐associated mutant form progerin.