CD4 and bacterial sexually transmitted disease: administration of IL-12 encapsulated in biodegradable microspheres (hereafter designated IL-12/ms) during gonococcal infection similarly promotes the development of Th1-driven immune responses, including production of IFN-γ by CD4+ T cells and specific IgG and IgA antibodies in serum and genital secretions, as well as accelerated clearance of the infection, without overtly toxic effects (8).