administration of IL-12 encapsulated in biodegradable microspheres (hereafter designated IL-12/ms) during gonococcal infection similarly promotes the development of Th1-driven immune responses, including production of IFN-γ by CD4+ T cells and specific IgG and IgA antibodies in serum and genital secretions, as well as accelerated clearance of the infection, without overtly toxic effects (8). Here, CD4 is linked to gonorrhea.