Noteworthy, some PC cells are unable to replicate the transcriptional interplay between ERα/ERβ (53, 54), and the most routinely used PC cells do not represent prostatic tissue, since in human prostate ERα expression is confined to stromal cells, while ERβ is expressed in the luminal and basal epithelial cells. The gene discussed is ESR1; the disease is pachyonychia congenita.