Because MAG has a higher HNK-1 epitope density than other myelin glycoconjugates leading to strong IgM antibody binding, removal of HNK with synthetized glycopolymers may prevent binding of anti-MAG IgM to human MAG.76 On this basis, in a mouse model for anti-MAG neuropathy, the glycopolymer PL84(mimHNK-1), designed as an autoantibody scavenger by mimicking the natural HNK-1 glycoepitope, effectively removed the pathogenic anti-MAG antibodies, offering promising potential for antigen-specific immunotherapy.77 The gene discussed is CD40LG; the disease is neuropathy.