EZH2 and neoplasm: Epigenetic silencing of the Th1-type chemokines CXCL9 and CXCL10 through mechanisms such as enhancer of zeste homolog 2 (EZH2)-mediated histone H3 lysine 27 trimethylation and DNA methyltransferase (DNMT) 1-mediated DNA methylation reduces effector T cell trafficking to the tumor microenvironment (31).