Further investigations, using TNFR2- and TNFR1/2-deficient mice clearly demonstrated that the TNFR2 signaling pathway lacked a clear inflammatory function while the outcome of the infection of mice deficient for both TNFR1 and TNFR2 was similar to the TNFR1-negative strain (39). Here, TNFRSF1B is linked to infection.