Moreover, even if YL1 had a stop codon mutation in GPR1, its transcript resulted upregulated at 1 h (logFC = 1.24) (Table S8 in Supplementary Material), differential expression of the ALS genes (55, 56), known to be involved in cell–cell or host cell adhesion and invasive growth, was also observed. Here, CMKLR2 is linked to amyotrophic lateral sclerosis.