IL1R1 and infection: A subsequent analysis of WT and interleukin-1 receptor (IL-1R)-deficient mice on the C57BL/6 genetic background did not identify significant differences in survival or fungal dissemination after intranasal infection with C. neoformans H99; however, at day 12 postinfection, the IL-1R−/− mice had a modest elevation of lung fungal burden (37).