Also, GMI-127 and GMI-1271, E-selectin antagonists developed by GlycoMimetics based on the bioactive conformation of sLex in the carbohydrate-binding domain of E-selectin, have been used in treatment of sickle cell crisis (ClinicalTrials.gov Identifier: NCT00911495) and as an adjuvant for chemotherapy of hematological malignancies, including multiple myeloma and acute myeloid leukemia (NCT02811822, NCT02306291). The gene discussed is SELE; the disease is acute myeloid leukemia.