By contrast, although the ratio of Th1 cells to CD4+ T cells also has reported pathogenicity for EAE and MS similar to the ratio of Th17 cells to CD4+ T cells (Goverman, 2009; Domingues et al., 2010), LH2171 administration did not decrease the Th1 cell to CD4+ T cell ratio, thus suggesting that LH2171 might have no influence on Th1 cell differentiation. Here, CD4 is linked to myeloid sarcoma.