IL-1β, TNF-α, and IL-6 stimulated the liver to produce high-sensitivity CRP (hs-CRP) (Yamashita et al., 2015), which had a strong relationship with the recurrent events of cardiovascular diseases as shown in several randomized clinical trials (Ridker et al., 2011; Everett et al., 2013). This evidence concerns the gene TNF and cardiovascular disorder.