EDN1 and myocardial ischemia: Additionally, another study demonstrated that Danlou tablets [the only formula approved by the China Food and Drug Administration to treat PSCS with IHD (Yang and Wang, 2012)] reduced levels of serum resistin, endothelin-1 (ET-1), IL-6 and TNF-α, improved NO levels and relieved vascular endothelial injury in atherosclerotic model rats (Miu et al., 2016).