HMGB1 is an important inflammatory response mediator (Scaffidi et al., 2002), and HMGB1/toll-like receptors (TLRs) have been shown to play critical roles in liver inflammation and liver fibrosis (Mencin et al., 2009; Berzsenyi et al., 2011; Tu et al., 2012). Here, HMGB1 is linked to Hepatic fibrosis.