The spatiotemporal progression of NFT from the entorhinal cortex and the hippocampus to the isocortical areas has been shown correlated with cognitive deficits in the AD brain (Duyckaerts et al., 1997; Grober et al., 1999), supporting a pivotal role for tau pathology in AD-related memory impairments. Here, MAPT is linked to Cognitive impairment.