Increased energy expenditure, is a hallmark of ALS, and it is currently thought that the clinical, genetic and pathological continuum between ALS and FTD also extends to a metabolic continuum, with FTD patients tending to gain weight and ALS patients lose weight despite both diseases sharing similar alterations in food intake, insulin resistance and increased energy expenditure (Ahmed et al., 2016c). Here, INS is linked to frontotemporal dementia.