While OS and NS has been implicated in many diseases like AD, PD, ALS (Bergeron, 1995; Good et al., 1996; Jenner and Olanow, 1996; Giasson et al., 2002) and Kii ALS/PDC (Morimoto et al., 2009), OS and NS may be promoted by genetic predisposition and/or environmental factors accumulated in the high incidence area or lower the cellular capacity to compensate for such insults. This evidence concerns the gene PDC and Parkinson disease.