Overall, the positive expression of 8-NG, iNOS, NF-κB and 8-OHdG was 100, 100, 100, and 86% of cells, respectively, in the hippocampal area including hippocampus, prosubiculum, subiculum, presubiculum, and parahippocampal gyri in the cerebrum of the Kii ALS/PDC patients. The gene discussed is NOS2; the disease is amyotrophic lateral sclerosis.