HSPA1A and malignant colon neoplasm: HSP70 expression was significantly increased in SW480 colon cancer cells early after exposure to hyperthermia and particularly after profound hyperthermia of 43°C (HSP70 1A [HSPA1A] at 0.5 hours: 41°C = FD 2.7, 43°C = FD 30.0 versus normothermic control = FD 1) (Figure 4A, top).