In summary, our findings from in vitro mechanistic studies as well as investigation of peritoneal colon cancer metastases after a HIPEC procedure indicate that induction of HSP27, HSP70, and HSP90 expression through hyperthermic and cytostatic stress in colon cancer cells actively inhibits apoptosis-inducing effects during and after the exposure to HIPEC-induced stress. Here, HSPA1A is linked to malignant colon neoplasm.