Heat shock proteins are known to play a crucial role in chaperoning misfolded proteins and protecting cells from damage and overexpression of HSPs in various tumor entities in association with poor prognosis.14,15,19,20 Previously, we demonstrated upregulated HSP27, HSP70, and HSP90 mRNA and protein expression in tumors from PC of different entities after clinical HIPEC procedures. Here, HSPA1A is linked to pachyonychia congenita.