ERBB2 and neoplasm: It blocks the intracellular mitogen-activated protein kinase cascade (RAS/RAF/MEK/ERK) and the phosphoinositide 3-kinase (PI3K/AKT/mTOR) pathway, arresting the cell cycle in G1 phase [8], and promotes ubiquitination, endocytosis, and degradation of HER2, decreasing its expression on the tumor cell surface [9, 10].