ERBB2 and breast cancer: A meta-analysis of 5 randomized trials, comprising 515 patients, concluded that the addition of trastuzumab to chemotherapy for HER2-positive BC in the neoadjuvant setting improves the likelihood of achieving a higher pCR rate (odds ratio (OR): 1.85, 95% CI: 1.39–2.46; p value < 0.001) with no additional toxicity [62].