These results concluded miR-429 and CRKL regulates HepG2 cell migration and invasion via Raf/MEK/ERK-EMT pathway, which also revealed the mutual influence relationship between miR-429 and CRKL, providing a novel insight for investigating the combined power of miR-429 and CRKL in HCC field. The gene discussed is CRKL; the disease is hepatocellular carcinoma.