PRF1 and neoplasm: Consistent with the RNA-sequencing data and RT-PCR results, dNP2-siChi3l1-treated mice showed increased gene expression of anti-tumor immunity molecules CTSE, TRAIL, IFNγ, T-bet, Perforin, and Granzyme B, while the levels of Th1-inhibitory molecules such as Twist1 and SOCS1 were significantly down-regulated (Fig. 9i).