In turn, increased IFNγ signaling in Chi3l1 KO T cells shows more potent tumor-killing activity with increased tumoricidal expression of molecules such as CTSE, TRAIL, and Granzyme B. Previously, IFNγ has been shown to increase the expression of ctse36 and trail37, which contribute to tumor clearance in mice37–39. This evidence concerns the gene IFNG and neoplasm.