TNF and neoplasm: Furthermore, when we started to treat dNP2-siChi3l1 intranasally at 2 days after intravenous tumor injection as a therapeutic scheme, it also still significantly decreased the number of tumor colonies in the lung with increased expression of IFNγ and TNFα expressing CD4 and CD8 T cells suggesting it could inhibit tumor growth in the lung as a therapeutic agent (Supplementary Fig. 10).