Female mice exhibited diabetes-induced downregulation of glucokinase (Gck, 47% decrease, p < 0.05) and upregulation of phosphofructokinase 2 (PFK, 16% increase, p < 0.05), glycogen debranching enzyme (Agl, 48% increase, p < 0.05), glycogen phosphorylase (Pygm, 26% increase, p < 0.05) and glycogen synthase kinase 3β (GSK3β, 22% increase, p < 0.05) (Fig. 7B). This evidence concerns the gene GSK3B and diabetes mellitus.