Using this platform, we tested the quantitative and qualitative changes in neurospheroids morphology, size and neurite extension in the presence of multiple compounds including the inhibitors of \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${\rm{\beta }}$$\end{document}β– and γ–secretases, which have been primary targets for AD drug discovery. This evidence concerns the gene PPIB and Alzheimer disease.