N-cadherin downregulation decreased the clonogenicity and soft agar colony formation compared to the FGFR4-388Arg-overexpressing cell line and the empty vector control cell line (Fig. 4B,C), and the same effects were reported in vivo in tumor growth of xenografts in inmunodeprived mice with these cell lines (Fig. 4D). The gene discussed is CDH2; the disease is neoplasm.