SHOC2 and RASopathy: Six (9.5%) were found in SOS1; two (3.1%), in RAF1; three (4.7%), in KRAS; three (4.7%), in MAP2K1; two (3.1%), in RIT1; two (3.1%), in BRAF; and two (3.1%), in SHOC2. These mutations have been previously reported in medical literature and various mutation databases (Table 1), and the clinical features of these patients were compatible with RASopathies (Fig. 1 and suppl.