Since miR-146a and miR-181b are involved in modulating the expression of E-selectin and the adhesion of colon cancer cells to endothelial cells, we next studied whether they modulate the TEM of metastatic colon cancer cells by tuning their capacity to penetrate a Boyden chamber membrane coated with a tight layer of HUVECs transfected with miRNA inhibitors or their control. The gene discussed is SELE; the disease is malignant colon neoplasm.