E-selectin interacts with colon cancer cells by binding to various counter-receptors constituted by a scaffold containing the Sialy Lewis a/x tetra-saccharide carbohydrate borne by signalling proteins including CD44v, CEA, PODXL, MUC16 and death receptor 3 (DR3)2,33–37. The gene discussed is MUC16; the disease is colonic neoplasm.