MYC and cancer: In order to exclude the possibility that the decrease of AR and PSA might be induced by suppressed cell growth post BMI1 knockdown, we first knocked down c-Myc or aurora kinase A (AURKA), which are well-known oncogenes and regulate cancer cell growth8, to dramatically suppress cell growth, and found that AR or PSA levels were not downregulated (Supplementary Fig. 1a, b).