LncRNAs data have been validated in spinal cord, as main involved tissues in ALS and the study was extended to a little group of patients with mutation in genes associated to ALS, i.e. FUS, SOD1 and TARDBP. Furthermore, we have investigated the presence of co-expression networks between coding and lncRNAs. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.