After 52 weeks of treatment CANA did increase the body weight change in WD-fed MC4R-KO mice (Fig. 5b), and all the animals from both groups developed liver tumors; however, 52-week CANA treatment significantly reduced the number of tumors in the liver of WD-fed MC4R-KO mice with a trend towards a reduction in maximum tumor size (Fig. 5c and d). The gene discussed is MC4R; the disease is neoplasm.