HUWE1 and cancer: In the case of the FASTKD2-PANK1-HUWE1 triple, a higher risk of cancer recurrence was associated with increased expression of the HUWE1 gene and lower expression levels of FASTKD2 and PANK1. The FASTKD2 gene, which has the greatest weight in the classifier for this triple, has been previously shown to promote apoptosis of cancer cells72.