(B–C) 3T3-L1 adipocytes were treated to induce insulin resistance with and without 10 μM CoQ9 supplementation as indicated before determination of insulin sensitivity by HA-GLUT4 abundance at the plasma membrane (PM) in unstimulated cells and in response to 100 nM insulin (B) or by suppression of lipolysis by 0.5 nM insulin (C; calculated from Figure 4—figure supplement 1C–E as described in the Materials and Methods). The gene discussed is INS; the disease is Insulin resistance.