COQ7 and Insulin resistance: Similarly, siRNA knock down of the key regulatory proteins in CoQ biosynthesis that were down-regulated in insulin-resistant mouse and human adipose tissue (Coq7 or Coq9) (Figure 5—figure supplement 1C–D) lowered mitochondrial CoQ9 (Figure 5D) and triggered insulin resistance (Figure 5E–5F, Figure 5—figure supplement 1E).