Moreover, the comprehensive characterization of GC carried out by The Cancer Genome Atlas (TCGA) network revealed oncogenic mutations in central Wnt pathway components, including CTNNB1 (β-catenin), APC and FBXW7 (F-box/WD repeat domain-containing 7), an antagonist of the Wnt signaling that targets β-catenin for degradation [26]. Here, FBXW7 is linked to gastric cancer.