CLDN8 and metastatic malignant neoplasm in the lymph nodes: As shown in Table 2, the expression of claudin-8 was not related to age (P = 0.846), Ki67 expression (P = 0.472), histological grade (P = 1.000) or clinical staging (P = 1.000), whereas it was positively related with lymph node metastasis (P < 0.01).