In our study, correlations between the expression of claudin-5 and claudin-8 and lymph node metastasis were also observed, which revealed that the expression levels of claudin-5 and claudin-8 also have the potential to be established as prognostic indicators in patients with nasopharyngeal carcinoma. The gene discussed is CLDN8; the disease is metastatic malignant neoplasm in the lymph nodes.