As it displayed in Table 1, the expression of claudin-2 was not associated with age (P = 0.896), the expression of Ki67 (P = 1.000), histological grade (P = 0.472), clinical staging (P = 0.364) or lymph node metastasis (P = 0.792). This evidence concerns the gene MKI67 and metastatic malignant neoplasm in the lymph nodes.