As shown in Table 4, individuals whose SMI increases were > 1% over a year had AHRs of 0.71 (95% CI 0.59–0.84, P < 0.001), for developing metabolic syndrome compared with individuals whose SMI changes were < 0% after adjusting for age, sex, BMI, family history of diabetes, smoking, exercise, and CRP levels, (Model 4). This evidence concerns the gene CRP and diabetes mellitus.