Moreover, PNS increased the activity of miR-181b, stimulated the activity of the mTOR/Akt pathway, decreased LC3-II and Beclin1 expressions, reduced the number of phagophores, autophagosomes and autolysosomes, reduced autophagy, and ameliorated taurocholate-induced AP. Here, BECN1 is linked to alkaline phosphatase measurement.