EGFR and adenocarcinoma: The odds of EGFR mutation were significantly higher (P < 0.0001) in females versus males (odds ratio 1.85; 95% confidence interval 1.48, 2.32), never smokers versus ever smokers (3.64; 2.91, 4.56), and adenocarcinoma versus other histological sub-types (2.94; 2.17, 4.08).