Another study in African Americans revealed that ABCA7 rs115550680 is linked to the development of late-onset AD, in which the effect size (OR = 1.79; 95% CI = 1.47–2.12) is comparable with that of APOE ε4 (OR = 2.31; 95% CI = 2.19–2.42) [24]. This evidence concerns the gene APOE and Alzheimer disease.