ABCA7 and Alzheimer disease: In addition, although ABCA7 rs142076058 (p.Arg578Alafs) is likely rare in Caucasians, it is relatively common in African Americans and has been identified as an AD risk allele; MAF 15.2% in AD vs. 9.74% in controls (OR = 2.13; 95% CI = 1.42–3.20) [25].