Of note, in 2015, Steinberg et al. comprehensively analyzed rare premature termination codon (PTC) mutations in ABCA7 using whole genome sequencing and demonstrated that they are associated with AD risk in an Icelandic population; when analyzed by combining those rare “loss-of-function” variants, the OR is calculated to be 2.12 [29]. Here, ABCA7 is linked to Alzheimer disease.