In an African American cohort, a coding variant of ABCA7 rs3764647 (p.His395Arg), located near rs3752246, has been associated with AD risk (OR = 1.32; 95% CI = 1.07–1.63), while no or a minimal significant association was detected in rs3752246 and rs3764650, respectively [23]. This evidence concerns the gene ABCA7 and Alzheimer disease.