VEGFA and fibrosarcoma: However, intermediate model between ameboid and mesenchymal has recently been proposed, suggesting that cells may shift between the types of migration according to many factors, such as changes in microenvironment plasticity, loss of close cell-cell connections (tight junctions), availability of the vascular endothelial growth factor (VEGF) isoforms as observed for fibrosarcoma [130] or chemokines and growth factors released by inflammatory cells as reported for microvascular endothelial cells [126,131].