HFE and hereditary hemochromatosis: Several studies have suggested that heterozygosity for HFE gene mutation, the most common mutation type of hereditary hemochromatosis, can exacerbate chronic liver diseases, presumably via increased iron accumulation [12,13,14]; however, the role of HFE mutation in the pathology of NAFLD and chronic hepatitis C has not been confirmed [15,16,17,18].