BTN3A1 (CD277) is acting as a strong antigen-presenting molecule of both, IPP (prenyl-pyrophosphate, which is a product of eukaryotic cells) [119,120] and HMBPP ((E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate, which is a product of cancer cells and certain selected pathogenic bacteria, such as Mycobacterium bovis, Mycobacterium tuberculosis, Listeria monocytogenes, as well as certain species of malaria protozoa) for the γδ T-cells [121]. This evidence concerns the gene BTN3A2 and malaria.