KMT2A and acute myeloid leukemia: Similarly, in other studies, miR-181 was also observed increased in cytogenetically abnormal AML (CA-AML) with favorable cytogenetic abnormalities, such as t(15;17) (favorable risk), and decreased in CA-AML with unfavorable cytogenetic alterations, such as MLL-rearrangements (adverse risk) [23,46].